In: Nursing
Factor |
Affect |
Age | |
Disease | |
processes | |
Nutrition | |
Hydration |
In the table below, outline how the listed factors affect the action of drugs?
Factor | Effect on the action of the drug |
Age |
with increse in the age the lean mass of the body , fat decreases, it decrese the volume of distribution of the drug in the body. further the kidney and liver functioning with age is decreased causing the toxicity of the drug at the same dose of the drug |
Disease | In disease condition like in case of the liver diseases the protein like the albumin level in the body decreses and thus affects the protein binding of the drug and thus affects the ultimate action of the drug |
processes | various processess like the metabolism and also affects the action of the drug . incraesed metabolism by any factor decrese the level of the drug and decreesed metabolizing factor cause the toxicity of the drug at the normal dose. |
Nutrition | Various nutritive substances affects the action of the drug like milk reduces the absorption of ciprofloxacin as ca+ or other di or tri valent ions present in the milk make the insoluble complex with ciprofloxacin and thus reduce the absorption of the drug affecting the ultimatte action of the drug |
Hydration | Hydration of the body spcially the skin affects the topical action of the drugs in case when the drug is applied as ointment and cream form |