Question

C)Why during given Live virus vaccine, we have to be sure there is a gap : should be at least three weeks before or three months after an injection of immunoglobulin(Ig).

Answer 1

Immunoglobulin decrease protectivity of vaccines or inactivate vaccines directly . The efficiency of live virus vaccines may decrease, if administered before three weeks of administration of IVIG (standard or hyperimmunglobulin) or in 3 months after administration of IVIG. Since IVIG supresses especially the response to measles vaccine for a very long time depending on the dose, MMR vaccine should be administered 8 months after administration of IVIG. Although the effect of IVIG treatment on varicella vaccine is not known fully, it shouldshould be postponed 8 months as with MMR vaccine. If MMR and varicella vaccines have been administered within 14 days before IVIG, they should be repeated after IVIG (8 months). Transfusion of washed erithyrocyte suspension does not postpone administration of live vaccine. However, MMR and varicella vaccines should be administered three months after (other) erithyrocyte suspension transfusion, 6 months after whole blood transfusion and 7 months after plasma and platelet transfusion. Since oral polio vaccine, rotavirus, live influenza virus, all inactive vaccines are not affected by blood and blood product transfusions, they can be administered in accordance with the vaccination schedule