Question

what is the treatment plan for mesthesia gravis(MG)

Answer 1

Treatment plan for Myasthenia Gravis (MG)

There is no cure for myasthenia gravis, but treatment with immunosuppressants or cholinesterase inhibitors can help control symptoms.

Various treatments, alone or in combination, can relieve symptoms of myasthenia gravis. Your treatment will depend on your age, how severe your disease is and how fast it's progressing.

Medications

• Cholinesterase inhibitors. Medications such as pyridostigmine (Mestinon, Regonal) and neostigmine (Bloxiverz) enhance communication between nerves and muscles. These medications aren't a cure, but they can improve muscle contraction and muscle strength in some people.

  Possible side effects include gastrointestinal upset, diarrhea, nausea, and excessive salivation and sweating.

• Corticosteroids. Corticosteroids such as prednisone inhibit the immune system, limiting antibody production. Prolonged use of corticosteroids, however, can lead to serious side effects, such as bone thinning, weight gain, diabetes and increased risk of some infections.

• Immunosuppressants. Your doctor might also prescribe other medications that alter your immune system, such as azathioprine (Azasan,, Imuran) mycophenolate mofetil (Cellcept), cyclosporine (Sandimmune) methotrexate (Trexall) or tacrolimus (Astrograf XL, Prograf). These drugs, which can take months to work, might be used with corticosteroids.

  Side effects of immunosuppressants, such as increased risk of infection and liver or kidney damage, can be serious

• SURGICAL TREATMENT: THYMECTOMY

  Thymectomy has a central role in the treatment of MG. In thymomatous MG, the tumor should be removed. Tumor histologic grade, excision margins, and any distal spread guide treatment decisions regarding any subsequent radiation, chemotherapy, and monitoring. Along with thymoma, the entirety of the thymus tissue should be removed. Improvement in myasthenic symptoms may or may not follow. In multimorbid patients with high operative risk, palliative radiation therapy as an alternate can also be considered.22