pathophysiology of Ulcer Right Great Toe?

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Pathophysiology of Ulcer Right Great Toe

Risk factors are previous lower extremity amputation ,history of a foot ulcer ,peripheral vascular disease , poor glycemic control , smoking etc

These risk factors produces oxidative stress on nerve cells and leads to neuropathy.
Additional nerve dysfunction follows from the glycosylation of nerve cell proteins, leading to further ischemia.
Those cellular changes manifest in motor, autonomic, and sensory components of neuropathic foot ulcers.
Damage to motor neurons of foot musculature may lead to an imbalance of flexors and extensors, anatomic deformities, and eventual skin ulcerations.
Damage to autonomic nerves impairs sweat gland function, and foot may develop decreased ability to moisturize skin, leading to epidermal cracks and skin breakdown.
Then the patients may not notice foot wounds because of decreased peripheral sensation.
Because of blood supply required to heal a diabetic foot ulcer is greater than that needed to maintain intact skin, chronic ulceration can develop.

Nightingale answered 1 year ago

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