If the heparin is not effective in treating Clarence Hughes and his condition worsens, what other...

If the heparin is not effective in treating Clarence Hughes and his condition worsens, what other pharmacologic treatment might be helpful? Explain.

The patient was diagnosed with a PE and was started on heparin therapy. The question is just asking if the heparin does not work what are other ways to treat it with medications.

Expert Solution

Unfractionated heparin, Low molecular weight heparins and other anti coagulants are commonly used in the treatment of Pulmonary Embolism(PE).

Unfractionated heparin has some pharmacological limitations, mainly due to the aspecific binding to plasma proteins that limits its anticoagulant effect and causes the heparin resistance observed in some patients with PE and the inter-subject variability of the anticoagulant effect. Other antithrombotic agents such as LMWHs and selective thrombin inhibitors (hirudin and its analogues) do not aspecifically bind to plasma proteins. They have recently been used with promising results in the prevention and treatment of PE.

Nightingale answered 2 years ago

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