Question

5-Gastrointestinal drugs are drugs used to treat upper and lower gastrointestinal disorders.
i.
Discuss briefly the mechanisms of action of TWO major classes of drugs used to treat
gastric/duodenal ulcers.
ii.
Prescribe in addition to the above, a non-pharmacological treatment for the same health
conditions

Answer 1

Gastric and duodenal ulcers means a sore that develops on the lining of stomach ,oesophagus, and intestines caused by the acid secreted by the stomach,and gasttric cells.It is mainly caused by H Pylori infection and NSAID use inflammatiion.

1.Medications used to treat gastric ulcers and duodenal ulcers are

• Antibiotics.
• Proton pump inhibitors.
• H2 receptor antagonist.

Antibiotics- These are used to treat H pylori infections.

Proton pimb inhibitors. - These drugs blocks the gastric H,K-ATPase distrupt the secretion of gastric acid .This helps the healing of ulcers..

H2 receptor antagonist- These reduces the gastric acid secretion by binding to histamine, H2 receptor present in the gastric parietal cells.Thus prevents the action of ligand histamine.

Both the drugs are used to reduce the production of gastric acid and reduce the severity of gastric ulcers.

2.The ulcers can be managed without medications by some life style management.

• Reduce the weight if patient is over weight.
• Avoid caffeine chocolate, fatty and spicy foods.
• Eat dinner 3 to 4 hours before bed time.
• Reduce alcohol intake.
• Avoid NSAID use ,if needed take with meals and in a low dose.

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