Question

Velteri vs flolan – how set up and how they work. Amount of drug used. Types of diseases used on.

Answer 1

1) Veletri is injected with an infusion pump, usually through a permanent central intravenous (IV) catheter placed into a large vein such as in your chest. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Veletri medication is used to treat high blood pressure in the lungs (pulmonary arterial hypertension). It helps to increase your ability to exercise and improve symptoms such as shortness of breath and tiredness. It works by relaxing and widening the blood vessels (arteries) in the lungs and other parts of the body so that blood can flow more easily. This medication belongs to a class of drugs known as vasodilators. Veletri is a synthetic version of a substance found in the body called prostacyclin, an eicosanoid. It works by dilating blood vessels, preventing contraction of smooth muscle cells and reducing the stickiness of circulating platelets. The drug also helps the heart to effectively pump blood through the lungs.VELETRI, once prepared as directed is administered by continuous intravenous infusion via a central venous catheter using an ambulatory infusion pump. During initiation of treatment, VELETRI may be administered peripherally. Infusion sets with an in-line 0.22 micron filter should be used. Intravenous dosage Adults infusion rate is determined via a dose-ranging procedure. The infusion rate is initiated at 2 ng/kg/minute, then increased by 2 ng/kg/minute at intervals of >= 15 minutes until dose-limiting pharmacological effects are observed.
Whereas, Flolan is a prostaglandin (a hormone-like substance that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions. Flolan is used to treat pulmonary arterial hypertension(PAH) and improve your ability to exercise. When administered chronically, prepare FLOLAN in a drug delivery reservoir appropriate for the infusion pump with a total reservoir volume of at least 100 mL, using 2 vials of STERILE DILUENT for FLOLAN or 2 vials of pH 12 STERILE DILUENT for FLOLAN. It works by relaxing and widening the blood vessels (arteries) in the lungs and other parts of the body so that blood can flow more easily.This medication belongs to a class of drugs known as vasodilators. Each vial of FLOLAN contains epoprostenol sodium equivalent to either 0.5 mg (500,000 ng) or 1.5 mg (1,500,000 ng) epoprostenol, 3.76 mg glycine, 50 mg mannitol, and 2.93 mg sodium chloride.
Dosage Forms & Strengths
injectable, powder for reconstitution
0.5mg/vial
1.5mg/vial
Pulmonary Hypertension
Initial: 2 ng/kg/min IV infusion pump over 24-48 hours; may initiate at lower dose if intolerant to starting dose. Titrate by 1-2 ng/kg/min q15min or longer, until desired effect or dose-limiting pharmacologic effects occur.