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What characteristics of a cancer cell differentiates them from normal cells in terms of functionality? Are...

What characteristics of a cancer cell differentiates them from normal cells in terms of functionality? Are the protein receptors different? Biochemical associated with or released from cancer cells?

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Expert Solution

1. Based on functionality

Normal cells perform the function they are meant to perform, whereas cancer cells may not be functional. For example, normal white blood cells help fight off infections. In leukemia, the number of white blood cells may be very high, but since the cancerous white blood cells are not functioning.

2. Yes, protein receptors in normal and cancer cells are different. The cancer cell over expresses certain ligand receptors than the normal cells for eg. lung cancer cells over expresses folate receptors than the normal cells. Tumour cell often differ in the structure of cell surface markers present on them. These are known as Tumour associated glycopeptide antigens.

3. Cancer cells secrete substances that generate new blood vessels capable of providing nutrients and routes through which cancer cells can metastasize. Growth factors such as bFGF and VEGF can induce capillary growth(blood vessels) into the tumor. This is termed as angiogenesis.

gladiator answered 1 year ago
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