Below are 3 types of DNA crosslinking damage that can occur. Based on your understanding of...

Below are 3 types of DNA crosslinking damage that can occur. Based on your understanding of DNA repair, what mechanism would you predict would repair each and WHY?
1. Inter-Strand Crosslink:

Intra-Strand Crosslink:

Pyrimidine Dimer:

Solutions

Expert Solution

A. inter-strand crosslink damage is repaired by homologous recombination as the damage is in both strands and for this kind of repair uses template strand of another DNA is used for repairing.

B. Intra-strand crosslink is repaired by Base excision and nucleotide excision repair system. If only a single base is damaged BAse excision repair mechanism is used, But if 2-4 nucleotides are damaged Nucleotide excision repair system is preferred.

C. Pyrimidine dimer can be repaired by photoreactivation. Photoreactivation is a light-induced (300–600 nm) enzymatic cleavage of a thymine dimer to yield two thymine monomers. It is accomplished by photolyase, an enzyme that acts on dimers contained in single- and double-stranded DNA.

gladiator answered 1 year ago

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