Explain why aminoglycosides are administered for serious infection, not as a first choice for treating infection.

Explain why aminoglycosides are administered for serious infection, not as a first choice for treating infection.

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Expert Solution

Aminoglycosides are gram negative antibacterial medication.It inhibits the protein synthesis in a very short time and ceasing the multiplication of the bacteria causing infection .It Is used as an emperic therapy unless the susceptible causative organism is identified for serious infections like septicemia, complicated intra abdominal infection and UTILITY, nosocomila respiratory tract infection.

The major reason for it being the last choice is because of its irreversible damages and toxicity

It can cause inner ear toxicity which can lead to irreversible hearing loss.It depends on the antibiotics used ranging from 7 to 90% of hearing loss.

The other major effects are

Cardiac toxicity
Renal toxicity
Tinnitus in most of the patient

Thereby this drug though very beneficial and effective the side effects makes it less preferred choice to treat infection

Nightingale answered 2 years ago

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