A genetic deficiency of C3 leads to a type of immunodeficiency characterized by reccurent and severe...

A genetic deficiency of C3 leads to a type of immunodeficiency characterized by reccurent and severe infections. Explain why?

Expert Solution

gladiator answered 2 years ago

Genetic deficiency in RAG-1 and genetic deficiency in TAP1 both lead to the same outcome: severe...

Genetic deficiency in RAG-1 and genetic deficiency in TAP1 both lead to the same outcome: severe combined immunodeficiency (SCID), in which a patient has an almost completely nonfunctional adaptive immune response and is unable to fight off infections with normally harmless microbial organisms. EXPLAIN WHY deficiency in these two very different genes has the same clinical outcome. How will RAG-1 deficiency affect the immune system? How will TAP1 deficiency affect the immune system? How are these outcomes similar, and how...

1) Selective IgA Deficiency is the most common type of immunodeficiency reported for Caucasian populations. It...

1) Selective IgA Deficiency is the most common type of immunodeficiency reported for Caucasian populations. It is also strongly associated (by statistics, not because of co-location on a chromosome) with multiple types of of autoimmune disorders, including Graves Disease, Systemic Lupus Erythematosus, and Type I Diabetes. Given the concepts embedded in the Hygiene hypothesis and what we have managed to figure out about the role of IgA in human immunity, what does this observed association between IgA deficiency and autoimmunity...

What is JAK3 Severe combined immunodeficiency and IL2RG Sever combined immunodeficiency?

1. A genetic inability to produce intrinsic factor affects what cells? And leads to a deficiency...

1. A genetic inability to produce intrinsic factor affects what cells? And leads to a deficiency of what nutrient? Why? 2. Compare/contrast the roles of HCl and Bile.

Many cases of severe combined immunodeficiency disease (SCID) are caused by the lack of the enzyme...

Many cases of severe combined immunodeficiency disease (SCID) are caused by the lack of the enzyme adenosine deaminase (ADA). a. What pathway normally contains the enzyme ADA? b. How does the absence of ADA contribute to the non-functional immune system observed in SCID patients?

A patient is deficient of the complement protein C3. Describe one effect this deficiency could have...

A patient is deficient of the complement protein C3. Describe one effect this deficiency could have on inflammation.

A patient with recurrent Neisseria infections is evaluated for complement deficiency. C3, C4, and C5 levels...

A patient with recurrent Neisseria infections is evaluated for complement deficiency. C3, C4, and C5 levels are all within normal limits. CH50 values are below the reference range. What could explain these results? A. Patient has a deficiency of C1 B. Patient has non-functioning C4 C. Patient has non-functioning C5 D. Patient has a deficiency of Factor D

QUESTION 1A control deficiency that is less severe than a materialweakness, but important enough...

QUESTION 1A control deficiency that is less severe than a material weakness, but important enough to merit attention by those responsible for oversight of the company's financial reporting is referred to as a (n):a-Control deficiency.b-Inherent limitation.c-Reportable deficiency.d-Significant deficiency.QUESTION 2Auditors should consider materiality in the planning of an audit job. The materiality for planning is:a- Preliminary estimation of the auditors of the largest number of misstatements that would be important for any of the client's financial statements.b-Preliminary estimate of the auditors...

A functional mutation of the Apoc-2 protein leads to Hyperlipoproteinemia. This disorder is characterized by increased...

A functional mutation of the Apoc-2 protein leads to Hyperlipoproteinemia. This disorder is characterized by increased lipoproteins(eg. chylomicrons) in the blood. Explain as to how a functional mutation of Apoc 2 leads to this disorder.

What are some diseases or genetic abnormalities caused by dominant genes? Why are severe dominant genetic...

What are some diseases or genetic abnormalities caused by dominant genes? Why are severe dominant genetic diseases rarer than recessive ones?

Question