Question

What is the bioavailability of this ciprofloxacin? Assuming MR. Jones is in the hospital for XYZ infection but is taking all food and other meds by mouth, is there an advantage of giving him this med IV vs PO?

Answer 1

Bioavailability of Ciprofloxacin is – 70%.

Assuming MR. Jones is in the hospital for XYZ infection but is taking all food and other meds by mouth, is there an advantage of giving him this med IV vs PO?

If Mr. Jones is on Acetaminophen drug,

The 3 definitions accessible for acetaminophen are intravenous (IV), per oral (PO), and per rectal (PR). In spite of the fact that their pharmacokinetics are on the whole comparative, here's the manner by which they vary:

IV Acetaminophen

A nonexclusive adaptation of the Ofirmev remedy mark name plan isn't accessible, making IV acetaminophen essentially more costly than the PO or PR definitions.

The signs for IV acetaminophen incorporate gentle to direct torment, the transient lessening of fever, or direct to extreme agony when taken in mix with opioids. The item accompanies a discovery cautioning about the danger of pharmaceutical blunders that could conceivably bring about accidental overdose prompting passing and in addition dangers for liver poisonous quality. Contraindications incorporate touchiness responses and extreme liver harm or dynamic serious liver illness, while normal unfavorable impacts incorporate queasiness and spewing, migraine, and a sleeping disorder. More genuine antagonistic responses are liver damage, hypersensitivity, genuine skin responses (Steven Johnsons disorder, poisonous epidermal necrolysis), and extreme touchiness responses.

IV organization diminishes introduction to the liver by almost half as a result of first-pass digestion. Study comes about haven't regarded IV acetaminophen more powerful than the PR detailing for torment decrease in kids post-tonsillectomy; be that as it may, an opportunity to save takes longer with PR. IV acetaminophen additionally has a quick beginning of activity contrasted with a similar dosage of oral acetaminophen, and an opportunity to achieve crest plasma focus (Cmax) for IV organization is 30 minutes speedier than the PO plan. Study comes about have demonstrated Cmax happening close to the finish of 15 minutes with IV implantation, in which it can accomplish 70% more noteworthy Cmax than a similar dosage of oral acetaminophen.

In general, IV acetaminophen can give huge agony alleviation inside 15 minutes in the wake of starting implantation, and additionally huge fever lessening inside 30 minutes in the wake of starting imbuement. Study comes about demonstrate the Cmax of IV acetaminophen is 76% more prominent than PO and 256% more prominent than PR. The pinnacle cerebrospinal liquid fixations are 60% more noteworthy with IV organization than with PO and 87% more prominent with IV organization than with PR.

For endotoxin-incited fever, IV is supported over PO acetaminophen in decreasing temperature for up to 2 hours after organization. Following 2 hours, be that as it may, there is no measurably critical distinction.

The utilization of parenteral absence of pain is clinically justified when a patient has traded off gastrointestinal (GI) ingestion or can't take oral analgesics, or when 100% bioavailability is needed. It's additionally prescribed to progress from IV organization to PO when a patient can take or endure and ingest oral analgesics.