Question

explain pharmacokinetics and pharmacodynamics of drugs.

Answer 1

Pharmacokinetics

It is a branch of pharmacology. It is the study of how body affect the drug. Pharmacokinetics properties are affected of route and dose of drug administered as it affect the absorption rate of the drug. One of the model which explains the phases of pharmacokinetics called multi compartment model (LADME). It includes,

Liberation- The process of release of drug from the pharmaceutical formulation

Absorption- The process of substance entering into a blood circulation

Distribution- The dispersion of substances through out the fluid and tissues of the body

Metabolism- The process of Irreversible transformation of parents compounds into daughter metabolites

Excretion- The process of removal of substance from the body

Pharmacodynamics

It is a branch of pharmacology. It is the study of how drug affect the body It deals with the mechanism of action of the drug.The basic classification of mechanism of action includes,

1. Stimulation

2. Depression

3. Irritation

4. Replacement

5. Cytotoxic action

Pharmacodynamic properties are affected by the route and dose of drug administered. Pharmacodynamics concepts include,

Affinity- It is the attraction between the drug and receptor

Efficacy- Drug's ability to activate the receptor once it has bound to it

Potency- The amount of drug necessary to bring desired effect

Agonist/Antagonist

Desired effect / undesired side effects