When NSF is inactivated by NEM, the phenotype observed by the scientists was vesicle accumulation on...

When NSF is inactivated by NEM, the phenotype observed by the scientists was vesicle accumulation on the Golgi membrane. Indicate true (T) or false (F) statements below regarding the observation!

1. The NSF is inactivated, vesicles will only accumulate on Golgi membrane, not on the plasma membrane.

2. Vesicles accumulated on the Golgi membrane because NSF is responsible for providing the ATP to induce membrane fusion.

3. Vesicles accumulated on the Golgi membrane because no t-SNARE is available for fusion.

4. Vesicle fusion with the plasma membrane can also be inhibited by treating cell with botulinum neurotoxin.

Expert Solution

Answer:

1)Ttrue

2 )True

3) True

4) True

Explaination:

NSF is a soluble atpase which hydrolyse ATP to dissociate the SNARE apart SO FREE SNARE are available for binding to vesicles and this SNARE vesicle complex fused with target membrane.
But due to inactivation Of NSF the ATP hydrolysis does not occur to dissociate SNARE from SNARE vesicle complex fused with target membrane and hence no free SNARE available for vesicular transport to target membrane and their fusion with target membrane so resulting accumulation of vesicles on golgi membrane.
.While some recent study claim that NSF directly help in fusion of vesicles with target membrane on ATP hydrolysis.
Vesicle fusion with the plasma membrane can also be inhibited by treating cell with botulinum neurotoxin because this toxin cleavage the SNARE protein.

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gladiator answered 2 years ago

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