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Personal model creation requires understanding role of genomics. What is the critical information contributed by genomics?...

Personal model creation requires understanding role of genomics. What is the critical
information contributed by genomics? How will you use that in the model?

Solutions

Expert Solution

   Genome is a entire set of genetic material..Genomics is a DNA content present in one cell of an organism..It is a genetic concern focusing organism's genome..
    Canadian health environment eatablished projects in genomics and personalizes health..Bio medical research in canada produces highest impact factor publicants..Canada provides evidence based decision to implement non-invasive prenatal testing(NIPT) for aneuploidies(finding abnormal number of chromosomes)To prevent the families and patient from this rare disease cost effective diagnosis and therapeutic treatment is important..
Critical Information contributing Genomics:-
      Critical information about genomics is cancer genomes..that is abnormality in genes development many type of cancer..there are new method of diagnosis and treatment for this disease..Cancer caused by genetic and epigenetic changes in tumors get benefits from some drug called Vermurafenib.Food and Drug Administration(FDA) test treated the patient with melanoma(skin cancer) they have specific mutation in the BRAF genes..Mutation in HER2 gene developing breast cancer,esophageal cancer,bladder cancer ect...this cancers are detected by large scale that new technogy found that mutation and abnormal in DNA,RNA also produce the cancer..
   Researcher studies compare the genomics information about normal tumor and cancer..The wealth of data getting more information from patient medical history and clinical data..It is useful for reducing cancer risk,prognosis and for providing treatment and early diagnosis..Center for cancer Genomics(CCG) focused for now altered genes can promote cancer..It provide clinical advance for patient treatment.
Models:-
Analysis of cancer need diversity for identify in which genetic changes this cancer developed and genetic alteration that prevent cancer..This is a challenge role for research they need high quality bio samples for this studies..It increase contribution of data and expertise from cross-disciplinary teams..Cancer driver discovery Program(CDDP) needs the information about cancer development,metastasis and drug resistance..ALCHEMIST targeted to analysing patient for treatment with their drugs..
    Models of cancer must be tested..Cancer Treatment Discovery and Develpoment Program(CTD2) science lab studies discovered by genes linked to cancer and vulnerabilities with new therapies..
   Human Models cancer initiative(HCMI) researched how genomics charector have link with genomic traits and how cell behave..
   Division of Cancer Epidemiology and Genetics(DCEG) involve tissue profilling studies which normal cell are transformed into cancer cells..It also make research how environmental exposure like smoking,and radiation making biological changes in carcinogenesis and its risk factors..
   The cancer genomics cloud pilots reducing costs and increasing efficiency for data analysis..


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