In: Nursing
Personal model creation requires understanding role of genomics.
What is the critical
information contributed by genomics? How will you use that in the
model?
Genome is a entire set of genetic
material..Genomics is a DNA content present in one cell of an
organism..It is a genetic concern focusing organism's
genome..
Canadian health environment eatablished projects
in genomics and personalizes health..Bio medical research in canada
produces highest impact factor publicants..Canada provides evidence
based decision to implement non-invasive prenatal testing(NIPT) for
aneuploidies(finding abnormal number of chromosomes)To prevent the
families and patient from this rare disease cost effective
diagnosis and therapeutic treatment is important..
Critical Information contributing Genomics:-
Critical information about genomics is
cancer genomes..that is abnormality in genes development many type
of cancer..there are new method of diagnosis and treatment for this
disease..Cancer caused by genetic and epigenetic changes in tumors
get benefits from some drug called Vermurafenib.Food and Drug
Administration(FDA) test treated the patient with melanoma(skin
cancer) they have specific mutation in the BRAF genes..Mutation in
HER2 gene developing breast cancer,esophageal cancer,bladder cancer
ect...this cancers are detected by large scale that new technogy
found that mutation and abnormal in DNA,RNA also produce the
cancer..
Researcher studies compare the genomics information
about normal tumor and cancer..The wealth of data getting more
information from patient medical history and clinical data..It is
useful for reducing cancer risk,prognosis and for providing
treatment and early diagnosis..Center for cancer Genomics(CCG)
focused for now altered genes can promote cancer..It provide
clinical advance for patient treatment.
Models:-
Analysis of cancer need diversity for identify in which genetic
changes this cancer developed and genetic alteration that prevent
cancer..This is a challenge role for research they need high
quality bio samples for this studies..It increase contribution of
data and expertise from cross-disciplinary teams..Cancer driver
discovery Program(CDDP) needs the information about cancer
development,metastasis and drug resistance..ALCHEMIST targeted to
analysing patient for treatment with their drugs..
Models of cancer must be tested..Cancer
Treatment Discovery and Develpoment Program(CTD2) science lab
studies discovered by genes linked to cancer and vulnerabilities
with new therapies..
Human Models cancer initiative(HCMI) researched how
genomics charector have link with genomic traits and how cell
behave..
Division of Cancer Epidemiology and Genetics(DCEG)
involve tissue profilling studies which normal cell are transformed
into cancer cells..It also make research how environmental exposure
like smoking,and radiation making biological changes in
carcinogenesis and its risk factors..
The cancer genomics cloud pilots reducing costs and
increasing efficiency for data analysis..