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assessment are consistent with common bile duct obstruction? Explain the pathophysiologic changes that can cause these...

assessment are consistent with common bile duct obstruction? Explain the pathophysiologic changes that can cause these signs and symptoms associated with common bile duct obstruction. Clay colored stools Dark urine Steatorrhea Jaundice Pain with fatty food inta

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Expert Solution

An exocrine secretion of liver is bile this has to pass via a biliary duct to intestine.This produces cholesterol,bile salts,bilirubin.This helps on digestion of fat.  Half the bile produced runs directly from the liver into the duodenum via a system of ducts, ultimately draining into the common bile duct (CBD). The remaining 50% is stored in the gallbladder. In response to a meal, this bile is released from the gallbladder via the cystic duct, which joins the hepatic ducts from the liver to form the CBD.

The pathogenesis of cholecystitis most commonly involves the impaction of gallstones in the bladder neck, Hartmann’s pouch, or the cystic duct; gallstones are not always present in cholecystitis, however. Pressure on the gallbladder increases, the organ becomes enlarged, the walls thicken, the blood supply decreases, and an exudate may form. Cholecystitis can be either acute or chronic, with repeated episodes of acute inflammation potentially leading to chronic cholecystitis. The gallbladder can become infected by various microorganisms, including those that are gas forming.

Jaundice, a yellow discoloration of the skin and the sclera of the eyes, occurs when the common bile duct is obstructed because of an impacted stone in Hartmann’s pouch (Mirizzi’s syndrome).


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