How does GIP and GLP-1 stimulate insulin secretion?

Expert Solution

Sydney Mullin answered 2 years ago

Describe the events that occur during the manufacture and secretion of the insulin protein in a...

Describe the events that occur during the manufacture and secretion of the insulin protein in a pancreatic cell (eukaryotic cell). Begin with expression of the insulin gene. Be sure you describe the transcription, processing, and translation steps, giving detail for the initiation stage of transcription and translation (what features of DNA and RNA tell the machinery where to start and what machinery is involved). Once the protein is translated, describe the pathway and cellular organelles involved in the transport of...

Illustrate and explain how an elevation in plasma glucose levels leads to glucose-stimulated insulin secretion by...

Illustrate and explain how an elevation in plasma glucose levels leads to glucose-stimulated insulin secretion by pancreatic β-cells. Your illustration and explanation should include GLUT2, Glycolysis, TCA Cycle, Oxidative Phosphorylation, ATP, ATP:ADP, Kir6.2, calcium channel, synaptotagmin, secretory granules, proinsulin, insulin, and C-peptide.

a. How does regulated secretion differ from constitutive secretion? b. What would be the effect of...

a. How does regulated secretion differ from constitutive secretion? b. What would be the effect of mutating the KDEL sequence of a resident ER protein (like BiP)? Would this effect be similar or different from that of mutating the KDEL receptor protein? c.The pH of a compartment can be critical for association of a receptor and its cargo. How does the acidic pH of a late endosome result in different fates for the receptor and its cargo? d. Why are...

How does the Federal Reserve stimulate the economy? When faced between continued stimulus to stimulate the...

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When GLP-1 is released to the plasma, what are the target cells? What receptor does it...

When GLP-1 is released to the plasma, what are the target cells? What receptor does it bind to? Which intracellular signalling pathway is activated?

What is Human Capital? How does this stimulate Economic Growth? Explain. How does increasing the level...

What is Human Capital? How does this stimulate Economic Growth? Explain. How does increasing the level of education nationally help to improve Economic Growth, both in terms of the CFD and social progress? Why is it important to consider Human Capital in terms other than formal education? What are other forms of non-academic based Human Capital?

How does insulin, acting through the insulin receptor, exert "downstream" effects? In other words, what are...

How does insulin, acting through the insulin receptor, exert "downstream" effects? In other words, what are the consequences, at a biochemical/molecular level, of the binding of insulin to a cell, through the insulin receptor. Can you explain what this question is asking as well. Please list your sources. Thank you!

1. how does oral delievery of insulin occurs in human body? Also mention the role of...

1. how does oral delievery of insulin occurs in human body? Also mention the role of digestive system and liver for transporting the insulin into the blood stream (include related digestive enzymes) ? 2. Explain how gastric bypass surgery could cause anemia and which vitamin supplement is suggested to take to cure anemia? 3. What helps to compensate for the breathing rate in ketoacidosis? what happens when someone alters the breathing rate and how that would help to cure acidosis?

Match each event in the insulin secretion pathway with its correct order. A.Cytosolic ATP levels rise...

Match each event in the insulin secretion pathway with its correct order. A.Cytosolic ATP levels rise B.Cytosolic Ca2+ levels rise C.Membrane depoarization D.insulin secretory vesicles fuse with the plasma membrane E.K+ channel closes F.glucose enters the cell

How does Maturation Promoting Factor (MPF) stimulate cells to start prophase?

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