Match each event in the insulin secretion pathway with its correct order. A.Cytosolic ATP levels rise...

Match each event in the insulin secretion pathway with its correct order.

A.Cytosolic ATP levels rise

B.Cytosolic Ca2+ levels rise

C.Membrane depoarization

D.insulin secretory vesicles fuse with the plasma membrane

E.K+ channel closes

F.glucose enters the cell

Expert Solution

Correct order of insulin secretion

1) F) Glucose enters the cell

2) A) Cytosolic ATP levels rise

3) E) K+ channel closes

4) C) membrane depolarization

5) B) Cytosolic Ca2+ levels rise.

6) D) insulin secretory vesicles fuse with plasma membrane.

As Blood glucose increases ,there is a resultant flux of glucose through GLUT transporters in the beta cells.
Subsequently, within the beta cells, glucose is phosphorylated to glucose - 6-phosphate by glucokinase enzyme , which is the rate limiting step in insulin pathway.
This glucose-6-phosphate is metabloized in mitochondria producing ATP, hence cytosolic level of ATP increses
Increased level of ATP binds and closes ATP dependent potassium channels, channel closure blocks potassium exits from the Beta cell ,which causes membrane depolarization
Once the cell is depolarized , L-type voltage gated calcium channel are triggered and calcium channels are triggered, resultant influx of calcium and increased cellular calcium concentration.
Increased cytoplasmic calcium concentration leads to release of insulin and C peptide from a pool of insulin-containing docked secretory vesicles and migration of additional vesicles to membrane.

Sydney Mullin answered 1 year ago

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