The failure of monosomic individuals to survive is most closely connected with which of the following...

The failure of monosomic individuals to survive is most closely connected with which of the following terms?

		X-inactivation
		gene duplication
		haploinsufficiency
		gene redundancy
		inversion

Expert Solution

The failure of monosomic individuals to survive is most closely connected with Haploinsufficiency.

A monosomy is an aneuploidy that occurs when only one chromosome is present in a pair. For instance in turner's syndrome the chromosome count is 22 pairs+XO. Haploinsufficiency is when only one functional copy of gene is present (the other may be lost by deletion or inactivated) which cannot produce adequate amount of protein for normal functioning.

X inactivation occurs in all females (XX) one of the X is active whereas the other is inactive and called as barr body. If More than two x is present, XXX then only one X is active and the other two are barr bodies. In males X is active and there's no barr body. Since Y chromosome does not posses much genes as compared to X one of the X is inactivated in females to prevent them from having more gene products than men. X inactivation is not connected to The failure of monosomic individuals to survive

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gladiator answered 2 years ago

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