In: Nursing
Write proposal that describes an assessment of the needs of the client(s) and why you feel this project would be beneficial to improve health outcomes. Include the goal of the project, the target audience, and what you expect the response to be.
This proposal must be at least 2 pages in length, not counting the cover page and reference page, and be appropriately cited in APA format.
Project Title: ‘Effects of Heartfulness Meditation on genetic expression of cancer patients- a randomized controlled trial’
Project Summary:
An individual diagnosed with cancer have much impact on one’s self, family, and friends and in even caregivers. Diagnosing cancer ends with a completely life-changing experience. Physical and psychological symptoms such as pain, nausea, fatigue, the feeling of grief, fear and anxiety, fear of death etc. Even the family members and caregivers have the fear of losses and changes in their lives. People with cancer often feel depressed and have to face the self-image issues related to the treatment e.g. Chemotherapy. Almost all the cancer patients along with their family were stressful. During stress, the systemic nervous system triggers fight or flight response to increasing the production of nuclear factor- Kappa B [NF-kB] which is responsible for the regulation of gene expression to translate stress by the production of proteins called cytokines which cause inflammation in cellular level. It is beneficial if persists for a shorter duration and for a longer duration, prone to cancer, depression and other inflammation-related disorders. Infectious and non-infectious chronic inflammation leads to the progression of cancer. In the other hand, NF-kB gets induced by chemotherapy. As a part of cancer treatment, NF-kB inhibitors were used which also adds the risk that it can be detrimental due to its resistance to chemotherapy and its essential role in innate immunity. Recent researchers proved the benefits of Meditation in handling the stress and depression in a positive way and thereby reduce the production of NF-kB and other inflammatory markers responsible for cancer incidence. Hence we want to assess the effectiveness of Heartfulness Meditation in genetic expression of cancer patients who receive chemotherapy.
Keywords: Cancer, Inflammatory markers, nuclear factor - Kappa B, chemotherapy and Heartfulness Meditation
Introduction and need for the study:
NF-kB factor plays a pivot role in innate and adaptive immunity, inflammation, proliferation and death of cells. NF-kB signaling pathways are responsible to the cancer evolvement and its progression, response to treatment such as chemotherapy, radiotherapy, and pharmacological therapy.
In economic countries, the leading cause of mortality is cancer. Even in modern times, there is much advancement in detection and treatment modalities, still, cancer remains irremediable. When considered cancer, it is not one, it has manifold in its characteristics and treatment modalities. The biggest challenge in treating cancer is to understand and differentiate the epigenetic alterations and mutations of cancer genes which involved in disruption of normal processes. The one such big challenge was to differentiate irrelevant changes associated with cancer genotypes. These disruptions depend on the microenvironment of surrounding malignant cell. Mostly, the microenvironment is of inflammatory in nature. Thus the major role played by microenvironment gave us opportunities to innovate intervention targeting the inflammatory elements rather than proliferating cells, in order to prevent resistance to treatment [1-5].
Activation of NF-kB is involved in many inflammatory diseases like Asthma, Rheumatoid Arthritis, Bowel diseases, Atherosclerosis, Alzheimer’s disease, variety of human cancers etc. Activation of NF-kB plays an essential role in the pathogenesis of all inflammatory diseases. Irregularities in NF-kB pathway resulting in a variety of malignancies such as leukemia, lymphoma, solid tumors including breast, prostate, ovarian and colon cancers [6-23].
Inflammatory markers such as Interleukin-6, C - reactive protein, and Tumor necrosis factor-? level found to be associated with increased cancer risk even in healthy aging. We also want to assess the relationship between the levels of inflammatory markers in response to treatment and cancer prognosis.
There is disinclination in using the NF-kB inhibitors for treating cancer of certain types as it inhibits the efficacy of chemotherapy and even resistance in some cases. In reciprocity, the NF-kB inhibition resulting in enhancement of apoptosis activity in response to radiation [24-29].
Keeping all in mind the beneficial terms of reduction in NF-kB production and the possible undesirable effects of NF-kB inhibitors, we would like to intervene with Meditation through Heartfulness and assess its efficacy in reduction of NF-kB and to bring the desirable genetic expression in cancer patients.
Statement of the problem
“Effects of Heartfulness Meditation on genetic expression of cancer patients- a randomized controlled trial”
Objectives
Hypothesis of the study
H1: The mean clinical variables of cancer patients will be significantly associated with demographic variables at p < 0.05 level
H2: There will be significant association between the selected clinical variables of cancer patients and Heartfulness meditation intervention at p < 0.05 level
Operational definitions
Cancer Patient
A person who is receiving medical treatment for a malignant growth or tumor.
NF-?B
NF-?B (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
Delimitation
The study is delimited to,
Assumption
The study assumes that,
Variables
INDEPENDENT VARIABLES
Variables such as age, average age at cancer diagnosis, geographic location, gender, occupation, religion, type of residence, type of family, Body Mass Index, waist circumference, food pattern, Occasion of outside foods, type of soft drinks, and occasion of soft drinks, primary site of cancer- [Bladder cancer, Breast cancer, Cervical cancer, Colorectal (colon) cancer, Head and neck cancers, Kidney cancer, Leukemia, Liver cancer, Lung cancer, Lymphoma, Myeloma, Ovarian cancer, Prostate cancer, Skin cancer, Thyroid cancer, Uterine cancer, Vaginal and vulvar cancers.]
DEPENDENT VARIABLES
Interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-? (TNF-?) and NF-kB.
Materials and methods
Source of data
Data will be collected from Cancer patients who are receiving chemotherapy from selected cancer institutes in Chennai.
Method of collection of data
Diagnostic tests and structured questionnaire
Research design
An Experimental Research Design
Population
The population of present study comprises of Cancer patients who are receiving chemotherapy and got admitted in selected cancer institutes in Chennai.
Sample size
The study is planned to be conducted from the day of approval of funds and continued for a year.
Sampling technique
Non-probability purposive cluster sampling technique will be used.
Sampling criteria
INCLUSION CRITERIA
EXCLUSION CRITERIA
Data collection
It consists of two parts: part I and part II
Part I: Variables such as age, average age at cancer diagnosis, geographic location, gender, occupation, religion, type of residence, type of family, Body Mass Index, waist circumference, food pattern, Occasion of outside foods, type of soft drinks, and occasion of soft drinks, primary site of cancer- [Bladder cancer, Breast cancer, Cervical cancer, Colorectal (colon) cancer, Head and neck cancers, Kidney cancer, Leukemia, Liver cancer, Lung cancer, Lymphoma, Myeloma, Ovarian cancer, Prostate cancer, Skin cancer, Thyroid cancer, Uterine cancer, Vaginal and vulvar cancers.]
Part II: Diagnostic tests measuring Interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-? (TNF-?) and NF-kB.
Data analysis method
The data analysis is through descriptive and inferential statistics
Frequency, mean, mean percentage and standard deviation of complete demographic variables.
Parametric/nonparametric test, chi-square (?2) test applicable for the data will be used to find out the relationship between selected demographic variables and clinical variables among Cancer patients.
Does the study require any interventions to be conducted on patients or other humans or animals?
YES – It requires the invasive procedure of collecting blood samples for diagnostic evaluation.
Has the ethical clearance been obtained from your institutions?
Permission will be obtained from concerned institute ethical committee.
References