Question

For the following question, please answer in essay format( a page and half long minimum)( if hand written please print legibly and be clear about which part of the question are answering, in complete sentences, with as much detail as possible. Thanks!

Describe the electron acceptors required for electron transport and oxidative phosphorylation along the inner mitochondrial membrane. List all 6 electron acceptors (including protein complexes integral to the membrane, non-protein electron acceptors, and peripheral protein electron acceptors), the substrate molecules or electron carriers that donate electrons to these acceptors, and the product molecules or electron carriers that accept electrons from these electron donors. Which of these six electron acceptors are responsible for pumping protons out the mitochondrial matrix and into the intermembrane space?

Answer 1

Electrons from NADH pass to ubiquinone via FMN, Fe-s . Electrons to a flavoprotein ( glycerol 3-p dehydrogenase) on the outer face of the inner mitochondrial membrane, from which they pass to ubiquinone. Acyl-CoA dehydrogenase ( the first enzyme of beta oxidation) transfer electrons to electron transferring flavoprotein (ETF), from which they pass to ubiquinone via ETF:Q oxidoreductase. Succinate dehydrogenase contains four different sub-units, C and D integral membrane protein, contain heme B, and a binding site for Q, A and B sub-unit extend into matrix, they contain three 2Fe-2s centers, bound FAD and A binding site for succinate. Electrons from succinate transfer to ubiquinone via FAD and 2Fe-2s centers. From reduce ubiquinone, electrons pass to cytochrome c via 2Fe-2s center of complex lll, cytochrome c is A soluble protein of the intermembrane space. After it's single heme accept an electron from complex lll, cytochrome c moves to complex lV to donate the electron to A binuclear copper center. In complex lV oxigen bind with heme a3, is reduce to it's peroxy derivative by two electron from Featured center. Delivery of 2 more electron from cytochrome c conversation peroxy derivative to 2 mol of water, with consumption of 4 substrate H+ from matrix.