what are some contraindications of protease inhibitors

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contraindications of protease inhibitors (PI)

those with high cholesterol, triglyceride in the blood PI s are a contraindicated as they worsen the dyslipidemia
Hyperuricemia (high amount of uric acid in the blood) or gout (a type of joint disorder due to excess uric acid)is a contraindication as it might cause exacerbation of symptoms
hemophilia will get worse due to the bleeding tendencies caused by ritonavir>indinavir
Following heart conditions like cardiomyopathy(a disease of the heart muscle), complete heart block, first-degree atrioventricular block, second-degree atrioventricular heart block, abnormal heart rhythm, etc as the risk for cardiac failure is more.PI has shown to have prolongation of the PR and QRS intervals which can cause cardiovascular collapse.
liver problems like abnormal liver function tests, liver failure as it can cause further liver dysfunction, liver failure
Known allergies to PI is an absolute contraindication

Nightingale answered 1 year ago

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