contraindications of protease inhibitors
(PI)
- those with high cholesterol, triglyceride in
the blood PI s are a contraindicated as they worsen the
dyslipidemia
- Hyperuricemia (high amount of uric acid in the
blood) or gout (a type of joint disorder due to
excess uric acid)is a contraindication as it might cause
exacerbation of symptoms
- hemophilia will get worse due to the bleeding
tendencies caused by ritonavir>indinavir
- Following heart conditions like
cardiomyopathy(a disease of the heart muscle), complete heart
block, first-degree atrioventricular block, second-degree
atrioventricular heart block, abnormal heart rhythm, etc as the
risk for cardiac failure is more.PI has shown to have prolongation
of the PR and QRS intervals which can cause cardiovascular
collapse.
- liver problems like abnormal liver function
tests, liver failure as it can cause further liver dysfunction,
liver failure
- Known allergies to PI is an absolute
contraindication