Question

Consider what you know about Mendelian Genetics. How does this play a role in people affected by sickle cell anemia who live in regions where malaria is present?

Answer 1

An Austrian monk named Gregor Mendel introduce a new theory of inheritance based on his experimental work with pea plants.Mendel believed that heredity is the result of discrete unit of inheritance , and every single unit or gene was independent in its action in an individual genome. According to this Mendelian concept , inheritance of traits depends on the passing on of these units. There three principle of Mendelian inheritance.

1.The law of dominance.

2.Law of segregation.

3.Law of Independent assortment.

- The mode of mendeMend inheritance are autosomal dominant ,autosomal recessive , X- linked dominant , X- linked recessive. It is also known as classical genetics.

- Sickle cell disease is a recessive Mendelian inheritance , in which each parents contribute one mutanat allele to an affected offspring.

- The Indivy who are carrier for the sickle cell disease have some protective advantage against malaria. As a result ,the frequency of sickle cell carriers are high in malaria endemic areas.