what is the difference between sickle cell anemia and thalassemia?

Expert Solution

Though Sickle cell anemia and Thalassemia are Genetic disorders, They differ in many ways.

SICKLE CELL ANEMIA	THALASSEMIA
RBC becomes sickle shaped , an abnormal Hb is formed( Hbs).	Decreased production of polypeptides ( alpha and beta) that will leads to decreased Hb , hence it is devided into alpha thalassemia and beta thalassemia
Commenly seen in African Americans	More commonly seen in mediterranean people
Sickle cells adhere to the walls of blood vessels and causing hypoxia by obstructing the blood flow, results a medical emergency called Sickle cell crisis.	Mild Thalassemia usually requires no active treatment.But some Patients shows an iron overload in their blood that will results to damage of vital organs like Heart,Kidney etc
Anemia mostly seen in homozygous patients, others are carriers.	Thalassemia major is a homozygous one , That requires active treatment( blood transfusion.
persons will be resistant to malaria	Persons will be more prone to infections., Screening can be done for fetus to detect this abnormality

Nightingale answered 1 year ago

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