43) What role does serum albumin play in fat metabolism?

A) It is a component of the chylomicron lipoprotein. B) It acts as a carrier for free fatty acids in the bloodstream. C) It binds hormone-sensitive lipase that is responsible for the release of triglycerides from adipocytes. D) It is involved in the transport of short-chained fatty acids across the plasma membrane.

44) The following fatty acid, in which the indicated carbon is labeled with ¹⁴C, is fed to an animal ¹⁴CH₃(CH₂)₉COOH After allowing 30 minutes for fatty acid β oxidation, the label would most likely be recovered in: A) beta-hydroxy butyryl-CoA. B) both acetyl-CoA and propionyl-CoA C) palmitoyl-CoA. D) propionyl-CoA.

Expert Solution

Ans. #43. B. The free fatty acids, being hydrophobic, are insoluble in aqueous solution. Albumin protein binds to free fatty acids and resultant hydrophilic complex (Fatty acid - Albumin) is transported through the aqueous bloodstream to various parts of the body.

# Chylomicron lipoprotein consists of triglycerides, phospholipids, cholesterol and apolipoprotein but no albumin.

# The transport of short-chain fatty acid across plasma membrane is mediated through specific transporter protein but not by albumin. Albumin is NOT a transporter protein.

# 44. D. propionyl-CoA.

During beta-oxidation of fatty acid, two C-atoms from C-terminal (including -COOH) are removed per turn.

The given fatty acid is 11C-long. So, when 2C are sequentially removed for 4 turn of beta-oxidation, the last 3C atoms form propionyl-CoA with the labelled C-atom in it.

# If propionyl-CoA is the terminal product of odd-chain fatty acid beta-oxidation. It does not undergo further round of beta-oxidation.

Therefore, the radiolabeled ¹⁴C will be retained in propionyl-CoA.

gladiator answered 2 years ago

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