Question

Complete this table. How does the dopamine levels differ with certain pathway, dopamine levels with first generation antipsychotics, and Second generation antipsychotics, and dopamine partial agonist drugs?

Dopamine Pathway	Dopamine levels in a patient without schizophrenia	Dopamine levels in a patient with schizophrenia	Dopamine levels with FGA (i.e. D2 antagonist)	Dopamine levels with SGA (i.e. D2/5HT2A antagonist)	Dopamine levels with a Dopamine Partial Agonist
Mesolimbic	unaltered
Mesocortical	unaltered
Nigrostriatal	unaltered
Tuberoinfundibular	unaltered

Answer 1

Dopamine is a hormone and neurotransmitter, which is normally synthesized in the brain. It helps in the normal functioning of body and mood and behavior. When it altered it produces many changes in the body and mood and behavior disorders. The functions of dopamine are maintaining heart rate, renal function, produces adequate sleep, controlling of nausea and vomiting, maintain mood stability, normal behavior, and good attention.

Dopamine pathway	Dopamine Level without schizophrenia	Dopamine levels in the schizophrenia	Dopamine level with first generation antipsychotic	Dopamine level with a second generation antipsychotics	Dopamine level with partial dopamine agonist
Mesolimbic	unaltered	Hyperactive causes psychosis symptoms	Blockade of D2 receptors reduces positive symptoms	Blocking of dopamine reduces positive symptoms	decreased reduces positive symptoms
Mesocortical	unaltered	Decreased causes negative and depressive symptoms	Blocking level of dopamine causes negative and cognitive symptoms	increaes of dopamine reduces negative symptoms and cognitive symptoms	increased dopamine reduces negative symptoms
Nigrostritial	unaltered	unaltered	Blockade of D2 receptors casues extrapyramidal symptoms	increases dopamine reduces extrapyramidal syndrome	increases dopamine reduces extrapyramidal symptoms than other mediaction
tuberoinfundibular	unaltered	unaltered	Blockade of D2 receptors causes hyperpprolactinemia	increases dopamine reduces prolactin level	increase doapmine reduces prolactin than other mediaction

doapmine levels in schizophrenia areincreased in the mesolimbic the doapmine pathways reduces dopamine in mesocortical areas, no changes in nigostritial, tuberoinffundibular

first generation antipsychotic acts  on the all the dopamine pathways and blockage doapmine level causes reduces positive symptoms and increases negative symptoms and causes increase prolactin and extra pyramidal symptoms

second geneartion antipsychotic acts on the mesolimbic and mesocortical causes reduced positive andreduced negative symptoms respectively and reduce prolactin and extrapyrmidal symptoms

Partial agonists acts dopamine pathways

Increased level of dopamine in mesolimic areas that causes schizophrenia. Partial agonists acts on the mesolimbic system that reduces positive symptoms by reducing dopamine

Decreased level of dopamine in the mesocortical area that causes negative symptoms. It acts on the mesocortical areas and increase level of dopamine there by reduces negative symptoms

It ascts on the nigrstritial and tuberinfundibular and increases dopamine that reduces parkinsonisum and prolactin levels compared to others