Question

In: Biology

What is characteristic of an enzyme-coupled receptor? How is it different from GPCRs? Discuss the activation...

What is characteristic of an enzyme-coupled receptor? How is it different from GPCRs?

Discuss the activation of a receptor tyrosine kinase and it's subsequent assembly of an intracellular signaling complex.

Describe the GTPase Ras in detail and what role does it play in regards to RTK.

Discuss the role of Ras in cancer. Is this a proto-oncogene or tumor suppressor gene and why?

What is MAP kinase? What time does it play in RTK?

Discuss the activity of the P1 3-kinase Akt with regards to apoptosis and cell survival.

Solutions

Expert Solution

Enzyme coupled receptors

-these class of receptors are utilized by peptide hormones

Consist a large extracellular ligand binding domain connected through a single transmembrane helical peptide chain to an intracellular subunit having enzymatic

Mutation GTPase ras result in permanently activated ras which result in overactive signaling inside the cell even absence of signal result cancer.

Mutated ras is most common oncogenes in humans.

Normally activated ras GTP is activated by enzyme called GAP .In mutated ras GTPase GAP is not functioned.

MAP Kinase is a mitogen activated protein kinsae

Which is activated in presence of direct mitogens,heart shock and proinflammatory cytokines.

It's functions include cell proliferation,g geneexpression,apoptosis and mitosis.

P13 kinase is enzyme activated by enzyme coupled receptors which will activate the enzyme PIP3 result activation of ATK

This ATK bind with BAX ,and prevent apoptosis

In absence of ATK ,BAX cause holes in the mitochondria and cause apoptosis.


Related Solutions

The G protein coupled receptor pathway involves the activation of many different proteins or synthesis of...
The G protein coupled receptor pathway involves the activation of many different proteins or synthesis of molecules. For the following pairs of proteins/molecules describe which of the pair is activated/synthesized by the other and how this occurs. a. protein kinase A and cAMP b. adenylyl cyclase and cAMP c. G protein coupled receptor and G protein d. protein kinase A and another protein kinase
QUESTION 1 Which of the following is an enzyme? a G protein a G protein-coupled receptor...
QUESTION 1 Which of the following is an enzyme? a G protein a G protein-coupled receptor ATP All of the above None of the above 1 points    QUESTION 2 Which of the following is true for all enzymes? They alter the transition state. They decrease ΔG. They provide energy for endergonic reactions. They harness energy from ATP. 1 points    QUESTION 3 The pathway of glycolysis can be found in: Anaerobic bacteria only Anaerobic species only All bacteria, but...
structure and function of G-protein coupled receptors: binding of neurotransmitter/ hormone to 7-transmembrane receptor, activation of...
structure and function of G-protein coupled receptors: binding of neurotransmitter/ hormone to 7-transmembrane receptor, activation of G protein (3 subunits- what happens with each subunit), role of GTP/GDP (AH domain)
Explain in detail how coupled enzyme assay works
Explain in detail how coupled enzyme assay works
How does an enzyme lower the activation energy? What are the specific catalytic mechanisms? What are...
How does an enzyme lower the activation energy? What are the specific catalytic mechanisms? What are the three types of specific catalytic mechanisms?
An extracellular signal, such as Epinephrine, acting through a G-protein coupled receptor can have quite different...
An extracellular signal, such as Epinephrine, acting through a G-protein coupled receptor can have quite different effect depending on multiple factors. Indicate at least 3 factors that would be responsible of these various cellular responses from a single extracellular signal.
1. How are SH2 and SH3 domains important in the activation of Ras by receptor tyrosine...
1. How are SH2 and SH3 domains important in the activation of Ras by receptor tyrosine kinases? 2. How is the regulation of the steady-state level of IP3 analogous to that of cAMP?
There are seven events when G-protein coupled receptor is activated. What are those seven steps.
There are seven events when G-protein coupled receptor is activated. What are those seven steps.
How does the enzyme-substrate complex actually work to lower the activation energy? I understand that that...
How does the enzyme-substrate complex actually work to lower the activation energy? I understand that that when the enzyme and substrate combine to form a complex, this is known as the transition state and in this state, the complex is unstable however it lowers the activation energy required. I just don't understand what about this complex lowers the activation energy
1. What is an enzyme? 2. How does an enzyme work? how does an enzyme, such...
1. What is an enzyme? 2. How does an enzyme work? how does an enzyme, such as amylase, break down polysaccharides? 3. how does this compare to your mechanism by which saccharides break down in the stomach? Explain. 4. Do all sugars produce glucose when they break down? 5. Why is mother's milk lactose instead of maltose? What might be the difference between the two? -A typed answer would be best, if not, please neat handwriting, thanks! :)
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT