Question

What is the patient most at risk for developing after the six dose of carbopLatin

Answer 1

Carboplatin is one of the most commonly used chemotherapeutic agents for ovarian, fallopian tube, and primary peritoneal cancer, as it is active against these types of cancers with usually well-tolerated side effects. Carboplatin is usually given by infusion into a vein (intravenous, IV) or intra-peritoneal, directly into the peritoneal cavity in the abdomen. The amount of Carboplatin to be dosed depends on many factors, including height and weight, patients general health or other health problems, and how the body responds to it. Doctor may determine the dose and schedule of dosing.
It was found in studies that the patient most at risk for developing hypersensativity reactions after the six dose of carboplatin
* The most commonly exhibited symptom associated with carboplatin hypersensitivity are as follows-
1. Hypotension
2. Hypotension followed by anaphylaxis
3. Desaturation
4. Some patient may experience mild signs and symptoms including skin rash
5. skin itching
6. Facial flushing
7. Dyspnea
8. Chest pain
9. Tachycardia
10. Paresthesias
11. Abdominal cramping
12. Diaphoresis
13. Some may experience following common side effects of low blood count, Nausea and vomiting usually occurring within 24 hours of treatment
14. Patient have been also reported following observation while on carboplatin treatment associated with taste changes, Hair loss, Weakness, Blood test abnormalities
15. Unusual bleeding or bruising
16. Black or tarry stools, or blood in stools or urine
17. Diarrhea (4-6 episodes in a 24-hour period)
18. Lip or mouth sores (painful redness, swelling or ulcers)
19. Extreme fatigue (unable to carry on self-care activities)
20. Muscle cramps or twitching
21. Change in hearing
22. Dizziness and confusion or visual changes

* Treatment and precautions upon toxicity related to carboplatin -
Upon the occurrence of symptoms and signs, carboplatin infusion should be immediately stopped and patients should be treated with intravenous fluid infusion and medications such as corticosteroids, antihistamines, and oxygen application.

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