Which of the following is correct with regard to the Asp residues in the middle of...

Which of the following is correct with regard to the Asp residues in the middle of the spinning rods of the F0 subunit of the ATP synthase?

They are protonated when facing the lipid bilayer membrane.

They are deprotonated when facing the lipid bilayer membrane.

They are 50% protonated when facing the lipid bilayer membrane.

They are charged when facing the lipid bilayer membrane.

Solutions

Expert Solution

Answer - They are deprotonated when facing the lipid bilayer membrane.

F1F0 ATP synthases use a transmembrane proton gradient to drive the synthesis of cellular ATP. The structure of the cytosolic F1 portion of the enzyme and the basic mechanism of ATP hydrolysis by F1 are now well established, but how proton translocation through the transmembrane F0 portion drives these catalytic changes is less clear. Here we describe the structural changes in the proton-translocating F0 subunit c that are induced by deprotonating the specific aspartic acid involved in proton transport. Conformational changes between the protonated and deprotonated forms of subunit c provide the structural basis for an explicit mechanism to explain coupling of proton translocation by F0 to the rotation of subunits within the core of F1. Rotation of these subunits within F1 causes the catalytic conformational changes in the active sites of F1 that result in ATP synthesis.

gladiator answered 1 year ago

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