If there is an affected heterozygous parent with Huntington’s disease (an autosomal dominant disease) who has...

If there is an affected heterozygous parent with Huntington’s disease (an autosomal dominant disease) who has children with an unaffected parent, what are the chances of them having kids with Huntington’s disease?

If there are two parents who are heterozygous carriers for Cystic Fibrosis disease (an autosomal recessive disease)
1. What are the chances of them having a child with Cystic Fibrosis disease?
2. What are the chances of them having a child who is a carrier for Cystic Fibrosis?
3. What are the chances of them having a child who is homozygous normal for this trait (not a carrier

Solutions

Expert Solution

Since the parent is affected and heterozygous, therefore the disease Huntington's disease must be dominant. Let the disease be represented by H. Thus, only H or HH can be diseased. If another parent be unaffected,the genotype has to be hh ( recessive,must be in pairs)

Thus,

Parents Hh x hh

Gametes H h h h

Offsprings Hh Hh hh hh

50% will be diseased and 50% unaffected.

Cystic Fibrosis,

2 parents who are heterozygous carriers. Since Cystic Fibrosis isa recessive disease, it will be expresed only when both are cc.

Let the normal be CC or Cc

2 parents are heterozygous carriers

Parents Cc x Cc

Gametes C c x C c

Offsprings CC Cc Cc cc

The first 3 offsprings wont get the disease. CC will be normal

Cc will be carriers.

cc will be affected.

a. 1 out of 4 i.e. 25% will be having the disease cystic Fibrosis.

b. 2 out of 4 will be carriers. Cc, 50% carriers.

c. 1 out of 4 will be a homozygous normal, 25%. CC.

gladiator answered 1 year ago

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