Question

1. What is the standard dose of the following drugs:
iv metoclopramide
Syrup nugel
Iv morphine
Iv omeprazole
Iv dns
Tab metranidazole
Syrup lactulose

Answer 1

Drug	Standard Dose
IV metoclopramide	Chemotherapy-Induced Nausea & Vomiting 2 mg/kg (infused over 15 minutes) 30 minutes before chemotherapy, then repeated 2 more times q2hr (after initial dose)   If Vomiting suppressed: Decrease dose to 1 mg/kg IV at frequency q3hr for 3 doses   If Vomiting not suppressed: Continue with same dose at frequency q3hr for 3 doses Diabetic Gastroparesis 10 mg IV/IM/PO q6hr 30 minutes before meals and at bedtime; use injectable dosing only if severe symptoms are present Small Bowel Intubation/Radiologic Examination of Upper GI Tract 10 mg IV over 1-2 minutes
Syrup nugel	Adult :10-20 ml   5 to 12 years : 5-10 ml q8h ; between each meals and at bedtime; also one can take a dose if needed, up to q1h
IV morphine	Direct Intravenous Injection: Adults : 0.1 mg to 0.2 mg per kg q4h as needed for pain management. Dose titration should be done according to the severity of pain, ADR reported, as well as the comorbidities and demographics.
IV omeprazole	Zollinger-Ellison syndrome 60 mg IV daily. Higher daily doses required and the dose should be titrated individually. When exceed 60 mg daily, divide the dose and give q12h.
Tab metranidazole	Sexually Transmitted Disease Prevention following sexual assault 2 g PO as a single dose 3-drug regimen that also include other standard drugs (CDC STD guidelines, 2010) Bacterial Vaginosis Nonpregnant women 500 mg PO BID x 7 days, OR 2 g PO qDay single dose, OR Extended-release: 750 mg PO qDay x 7 days Pregnant women 500 mg PO BID x 7 days, OR 250 mg PO TID x 7 days Colorectal Surgical Infection Prophylaxis; begin after mechanical bowel preparation the afternoon and evening before surgery 1 g PO q6-8hr for 3 doses Trichomoniasis 250 mg PO q8hr for 7 days; alternatively, 375 mg PO q12hr for 7 days 2 g PO qDay single dose; alternatively, 1g PO q12hr for 2 doses Amebiasis 500-750 mg PO q8hr for 5-10 days Gardnerella Infection Immediate release: 500 mg PO q12hr Extended-release: 750 mg PO qDay for 7 days; in empty stomach
Syrup lactulose	Constipation 15-30 mL (10-20 g) PO once daily; may increase to 60 mL (40 g) once daily Portal Systemic Encephalopathy Prophylaxis 30-45 mL (20-30 g) PO q6-8hr, adjust until 2-3 soft stools/day; acute: q1-2hr until 2-3 soft stools/day Treatment 20-30 g PO q1hr to induce rapid defecation; reduce to 20-30 g q6-8hr after defecation titrate to pass 2-3 soft stools/day

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