A 72 kg patient is started on a drug with an IV bolus dose of 180...

A 72 kg patient is started on a drug with an IV bolus dose of 180 mg. After 24 hours a dose of 80 mg is given, and after another 8 hours a dose of 120 mg is given. Using the principle of superposition determine the concentration of the drug 3 hours after the second dose and 2 hours after the third dose. The drug has a half-life of 9.2 hours and a volume of distribution of 0.105 L/kg. Elimination of the drug can be explained using a one compartment model and first order elimination kinetics.

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Amanda K answered 1 month ago

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