Hepatitis C pathophysiology?

Hepatitis C pathophysiology?

Expert Solution

Physiology of Hepatitis C Virus

single stranded RNA
Flavivirdae family > Hepacivirus
positive sense single stranded RNA
9.7 kb in length
Structural proteins: Core protein
Envelop protein E1

Envelop protein E2

non structural protein: NS2 and NS3, NS4A, NS4B, NS5A, NS5B
Host signal peptidase will cleave the structural protein from non structural protein
E2 - most variable region of HCV genome
Directly acting antiviral drugs- NS3, NS5A, NS5B

--- inhibitors: NS3> evir
NS5A> avir
NS5B> uvir

Core protein form viral nucleocapsid
E1 and E2 protein for viral assembly

P7 > ion channels for viral release

NS3 is the serine protease/ function as serine protease is enhanced by association with NS4A
NS5A - RNA binding site within replication complex
NS5B - is the RNA dependent RNA polymerase

Pathology of Hepatitis C virus

Virus cause inflammation of liver
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Microscopically spotted parenchyma cell degeneration
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Necrosis of Hepatocytes

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Cause diffuse lobular inflammatory reaction
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Disruption of liver cell cords

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Accumulation of macrophages near degenerating Hepatocytes

Nightingale answered 2 years ago

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