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In: Biology

Cancer cells have a high need for RNA, DNA, as well as energy (ATP) as they...

Cancer cells have a high need for RNA, DNA, as well as energy (ATP) as they rapidly divide. A precursor to the building blocks of RNA and DNA is Ribose-5-P (R-5-P). A high sugar diet has been shown to accelerate cancer growth. In terms of cellular metabolism, explain why a high sugar diet might be able to fulfill cancer cells high need for RNA, DNA, and ATP. For any metabolic pathways that intersect, be sure to identify the intermediate(s) that link the pathways.

Solutions

Expert Solution

the cancer cell can proliferate rapidly by using the mechanism of our body and any compound for division the uncontrolled division of cells leads to cancer this cancer needs their precursor as DNA RNA and protein to cell divide and metabolism so it can come from ultimately ou diet the nuclear material is basically made up of many components and in which the main component is the sugar that ribose 5 phosphates the sugars in the body mainly comes from the externally that is by the diet. and it also accelerates the rate of cancer in humans. Indeed, according to the World Health Organization, the average American consumes 126 grams of sugar a day, more than people in any other country, and nearly four times what nutritionists recommend. "It's an addiction," As we learn more and more about cancer metabolism, we understand that individual cancers are addicted to particular things. In a lot of cancers, that's insulin—and sugar.

the pathway.

researchers identified a new the PI3K, that would turn out to be a sort of master switch for cancer. The protein's normal function is to alert cells to the presence of insulin, prompting them to pump in glucose, cells' metabolic fuel. This signaling pathway is crucial to cells' growth, proliferation, and survival, so it makes sense that malfunctions can cause serious problems. Ii it runs slowly the body becomes insulin-resistant and cells fail to take up enough glucose: this is Type II diabetes. In cancer, however, the pathway shifts into high gear, providing tumors with an overabundant supply of glucose, which drives their growth. It turned out that the gene that encodes PI3K is the most frequently mutated cancer-promoting gene in humans—and in the years.

In many of the patients, the PI3K inhibitors cause blood sugar to spike, suggesting that the drugs meant to starve tumors were telling the liver that the body itself was starving, too. In response, the liver—which stores the extra glucose in the form of a compound called glycogen—was sending too much sugar into the blood, which triggered the pancreas to release excess insulin. Meanwhile, these patients' tumors continued to grow.

this study is by the Dr. Cantley and the publications can found in nature by Dr.hopkins


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