Name agents that enhance the action of PPI (proton pump inhibitors)

Expert Solution

The most common agents that enhance the action of proton pumb inhibitors are H2 blockers like famotidine and ranitidine.Now the PPIs have eclipsed the H2 blockers as the most commonly prescribed agents for problems that can be fixed or at least ameliorated by reducing stomach acid levels.PPIs combined with antibiotics eradicate helicobacter pylori also.

Pharmacology of PPIs

Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0, which allows selective accumulation in the secretory canaliculus of the parietal cell, and a benzimidazole with a second pK(a) of about 1.0. PPIs are acid-activated prodrugs that convert to sulfenic acids or sulfenamides that react covalently with one or more cysteines accessible from the luminal surface of the ATPase. Because of covalent binding, their inhibitory effects last much longer than their plasma half-life. All PPIs give excellent healing of peptic ulcers and produce good results in reflux esophagitis.

Nightingale answered 2 years ago

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