In: Nursing
What are lifespan considerations in geriatric patients? put in in ur own world.
THE changes in life have a dramatic effect on four phases of pharmacokinetics-drug aborpton, distribution,metabolism,and excretion
ABSORPTION
due to weakened gastro intestinal movement in the elderly and slow gastric emptying rate drugs stay longer in gastrointestinal tract,which is conducive to greater drug absorption
DISTRIBUTION
DUE TO decreased amount of plasma proteins, when the same dose of drug is used in elderly and young people ,the seniors have high level of free state and greater functionality
METABOLISM
For most of the seniors it is not common to have changes in liver function index but the activity of drug metabolism enzyme in the liver is decreased so that the HAIF -LIFE of the drug is prolonged-elderly are more prone to toxic reactions
DRUG EXCRETION
KIDNEY IS THE MAIN ORGAN INVOLVED IN DRUG EXCRETION
changes may results from reduced kidney functionality.It is most important factor in poroducing toxic drug reactions in elderly