What is the purpose of NaBH4 addition? What is the purpose of Amberlyst-15 addition? For the...

What is the purpose of NaBH4 addition? What is the purpose of Amberlyst-15 addition? For the synthesis of Ethyl Vanillyl Alcohol, and Methyl Diantilis Analogs.

Expert Solution

In general, NaBH₄ is reducing agent and it reduce the carbonyl compound into alcohol.

Commercially available Amberlyst-15 has played an important role in organic synthesis. Synthetic applications of Amberlyst-15 in different chemical transformations. Reactions include esterification, transesterification, Michael addition, aza-Michael addition, Prins cyclization, Friedel-Crafts alkylation, acylation, metal free hydro-arylation, hydroalkylation, halogenation, protection of carbonyls, amines, deprotection of acetals, acetates, Boc-protected amines, cleavage of epoxides, crossed-aldol condensation, synthesis of quinolines, pyrazolines, indolinones, acridines, calix[4]pyrroles, xanthenes, coumarins, benzopyrans theaspirane, furans, and substituted phosphonates. Applications of this catalyst allow mild and highly selective transformations and synthesis in a facile and environmentally friendly manner.

queen_honey_blossom answered 2 years ago

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What is the purpose of NaBH4 addition? What is the purpose of Amberlyst-15 addition? For the...

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