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In: Chemistry

What is the purpose of NaBH4 addition? What is the purpose of Amberlyst-15 addition? For the...

What is the purpose of NaBH4 addition? What is the purpose of Amberlyst-15 addition? For the synthesis of Ethyl Vanillyl Alcohol, and Methyl Diantilis Analogs.

Solutions

Expert Solution

In general, NaBH4 is reducing agent and it reduce the carbonyl compound into alcohol.

Commercially available Amberlyst-15 has played an important role in organic synthesis. Synthetic applications of Amberlyst-15 in different chemical transformations. Reactions include esterification, transesterification, Michael addition, aza-Michael addition, Prins cyclization, Friedel-Crafts alkylation, acylation, metal free hydro-arylation, hydroalkylation, halogenation, protection of carbonyls, amines, deprotection of acetals, acetates, Boc-protected amines, cleavage of epoxides, crossed-aldol condensation, synthesis of quinolines, pyrazolines, indolinones, acridines, calix[4]pyrroles, xanthenes, coumarins, benzopyrans theaspirane, furans, and substituted phosphonates. Applications of this catalyst allow mild and highly selective transformations and synthesis in a facile and environmentally friendly manner.


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