Beta-thalessemia is caused by mutations in the hemoglobin B gene we discussed along with sickle cell...

Beta-thalessemia is caused by mutations in the hemoglobin B gene we discussed along with sickle cell anemia. There are some anemia-causing mutations that are dominant while other mutations act in a recessive manner. The anemia caused by either type can be debilitating in affected genotypes and would be selected against in areas which do not have malaria.

a) Assuming both forms of beta-thalessemia in the affected genotypes show similar fitness relative to unaffected genotypes, which type of allele (recessive or dominant) will disappear more quickly from a population with a similar negative selection coefficient (s)? Explain why there is a difference.

b) Why would these mutations fail to disappear from a population in an area that has malaria-infected mosquitoes? Why do allele frequencies stabilize?

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gladiator answered 1 year ago

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