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[4/30/7] EXPLAIN WHAT IS THE WERNER SYNDROME AND THE GENETIC ALTERATIONS, THAT LEAD TO THE APPEARANCE...

[4/30/7] EXPLAIN WHAT IS THE WERNER SYNDROME AND THE GENETIC ALTERATIONS, THAT LEAD TO THE APPEARANCE OF THE SYNDROME AND ITS MANIFESTATIONS?


Typed please. (sometimes I can't understand the handwriting in some of the responses I get)]

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Werner syndrome is a condition that causes premature aging. People with this syndrome will develop and grow normally until puberty. At puberty, growth stops and adults with Werner syndrome are typically shorter than average. By the early 20s-30s, people with this syndrome develop conditions usually associated with more advanced ages. In addition, people with Werner syndrome have an increased risk of developing cancer, especially thyroid and skin cancers. Heart attack and cancer are the most common causes of death. Werner syndrome is caused by mutations in the WRN gene and is inherited in an autosomal recessive manner. This condition is diagnosed based on the symptoms and genetic testing. Treatment is based on individual symptoms and focuses on prevention of heart disease and cancer.

The WRN gene is important gene that produces the WRN protein which is involved in the DNA repair system. Hence in werner syndrome this gene gets mutated and the protein formed by the mutated gene is shorter than the usual protein and it doesnt enter the nucleus and hence the DNA damage cannot be repaired. Due to this drawback, the DNA damages accumulate and at the 20s or 30s of the affected individual gets diseases like cancer and also heart diseases. Thus the DNA damage is the main cause for the manifestation of the symptoms in the werners syndrome.`

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