Question

Please, I need a unique answer, use your own words (don't copy and paste, no handwritten notes)

give me an the biosynthesis and chemical structure of (Dexamethasone & COVID-19)

Answer 1

Dexamethasone is a corticosteroid (synthetic glcocorticoid) formerly used for anti-inflammatory and antialgic effects. It is tested on patients with COVID-19 in United Kindom's clinical trails and found to have benefits for patients in critical conditions. On treating the patients on ventilators, the mortality is cut off to one-third and by one-fifth in patients requiring oxygen. In Covid-19 patients, Dexamethasone dampens the immune response, when it becomes too aggressive.  

Synthesis:  

The first -substituted cortical steroid derivatives were synthesized by Taub in 1958, and obtained 16-methylprednisolone acetate which was considered as a potent steroidal anti-inflammatory agent. To synthesize Dexamethasone, 16-methylprednisolone acetate is dehydrated to 9,11 dehydro-dervative. It is then reacted with N-bromosuccinimide, a source of hypobromite, to form 9-bromo, 11-hydrin derivative which determines the epoxide ring closure. The formation of dexamethasone is made secondary to the ring opening reaction with hydrogen flouride in tetrahydrofuran.

The chemical formula of Dexamethasone is C₂₂H₂₉FO₅