Question

Can you solve followig the questions?

1- Select one proper scaffold and scaffold manufacturing method that would allow manufacturing osteoinductive scaffold, and briefly explain.

2- Define and explain two different adequate vasculogenesis strategies that you can apply to your scaffold.

3-Define and explain the biocompatibility process for CE certification.

Answer 1

1. Combination of both bio-electrospraying and the electrospinning has been recommended as more suitable for the cell growth anf the poliferation other than single electrospinning technique. It is the method that would increase the osteoconductive and osteoinductive effect with the particular regards to improved cell-scaffold interraction.

2. The mechanisms which are therapeutically stimulated by mainly two types of strategies

• Therapeutic aginogenesis which is the administration of angiogeneic factors either as a protein or a gene.
• Vascular regeneration which include the supply of new vascular or precursor cells.

3. The medical device manufacturers must need to demonstrate the compliance to the essential requirements that are laid down to the Medical Directive for CE marking of their product. One of the most important requirement for the technical file is the inclusion of the biocompatibility report and the biological evaluation of Medical Devices.