In: Biology
Actinomycin A is a drug that prevents successful translation by inhibiting elongation. The most likely direct effect of this drug is to prevent the:
a. Binding of the large ribosomal subunit to the small subunit
b. breaking of the bond between tRNA and its amino acid
c. disassociation of the ribosomal subunits
d. start codon from binding
e. formation of peptide bonds between two tRNAs
Ans) A
Binding of large ribosomal unit to smaller ribosomal unit. In cell biology,actinomycin A is shown to have the ability to inhibit transcription.Actinomycin A does this by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase.