Outline the steps of the ribosome cycle. At what stage do the ribosomal subunits bind to...

Outline the steps of the ribosome cycle. At what stage do the ribosomal subunits bind to each other? To mRNA? What causes them to dissociate when protein synthesis is complete?

Solutions

Expert Solution

1. Ribosome cycle:

a. Pre-initiation complex = small subunit, initiator tRNA on mRNA
b. Initiation complex = large subunit added
c. Elongation = aminoacyl-tRNA added, lengthen polypeptide
d. Termination = polypeptide exits into tertiary structure, ribosome disassembles

2. During initiation complex formation, the large ribosomal subunit binds to the small subunit to complete the initiation complex.

3. During pre-initiation complex formation, the small ribosomal subunit binds to the start of the mRNA sequence and then to the initiator tRNA to form the pre-initiation complex.

4. The post-termination complex formed by the end of the termination step consists of mRNA with the termination codon at the A-site, an uncharged tRNA in the P site, and the intact 70S ribosome. Ribosome recycling step is responsible for the disassembly of the post-termination ribosomal complex.

Once the nascent protein is released in termination, Ribosome Recycling Factor and Elongation Factor G (EF-G) function to release mRNA and tRNAs from ribosomes and dissociate the 70S ribosome into the 30S and 50S subunits.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

a. Outline the steps of the ribosome cycle. At what stage do the ribosomal subunits bind...

a. Outline the steps of the ribosome cycle. At what stage do the ribosomal subunits bind to each other? To mRNA? What causes them to dissociate when protein synthesis is complete? In detail. b. Outline the steps by which aminoacyl tRNA synthetases charge tRNAs. How can some organisms get away with having fewer than 20 synthetases, yet still charge tRNAs with all 20 amino acids? In detail.

1. Outline the steps of the ribosome cycle. At what stage do the ribosomal subunits bind...

1. Outline the steps of the ribosome cycle. At what stage do the ribosomal subunits bind to each other? To mRNA? What causes them to dissociate when protein synthesis is complete? 2. Outline the steps by which aminoacyl tRNA synthetases charge tRNAs. How can some organisms get away with having fewer than 20 synthetases, yet still charge tRNAs with all 20 amino acids?

Explain why the prokaryotic ribosomal subunits are defined as 30S and 50S, but the assembled ribosome...

Explain why the prokaryotic ribosomal subunits are defined as 30S and 50S, but the assembled ribosome is defined as 70S.

What is accounting cycle? Outline the basic steps included in accounting cycle.

What is a ribosome cycle? Explain.

What is translation, where does it occur? How many ribosomal subunits are there, and where are...

What is translation, where does it occur? How many ribosomal subunits are there, and where are they constructed? What are the P and A sites? What occurs during initiation, elongation, and termination and what are the three steps of elongation. What is the function of the stop codon?

A large ribosomal subunit is on the order of 3200 kDa. The diffusion limit of a nuclear pore is about 40kDa. How do ribosomal subunits ever reach the cytosol?

A large ribosomal subunit is on the order of 3200 kDa. The diffusion limit of a nuclear pore is about 40kDa. How do ribosomal subunits ever reach the cytosol? A.) Ribosomal subunits are endocytosed into the ER. B.) Karyopherin proteins help get them through the pore. C.) They eventually diffuse through the nuclear envelope bilayer. D.) Ribosomes can't get out, because karyopherins to not bind rRNA.

Outline the steps of Glycolosis, and the Krebs cycle. Identify the steps where ATP, NADH and...

Outline the steps of Glycolosis, and the Krebs cycle. Identify the steps where ATP, NADH and FAD are produced. Where, inside the cell, does each of these processes occur?

As a researcher, you develop a drug which blocks the ribosomal subunits from coming together. What...

As a researcher, you develop a drug which blocks the ribosomal subunits from coming together. What would be the implications to the cell? You also develop a drug that blocks the cis face of the golgi. What would happen to the cell?

1. Where does translation happen? What are the differences between ribosome and ribosomal subunit of prokaryote...

1. Where does translation happen? What are the differences between ribosome and ribosomal subunit of prokaryote and eukaryote? 2. What is codon? Who carry the codon and anticodon? 3. What is mutation? What are the type and causes of mutations? 4. Know everything about the gene transfer.

Subjects