In: Nursing
1. Chronic kidney disease involves progressive irreversible loss of kidney function . As a result there will be accumulation of fluid and nitrogenous waste products within the body due to improper excretion due to kidney damage. Symptoms will persists from weeks to months. Usually they will have creatinine clearance < 60mL/min/1.73 metersquare
2.Causes of Chronic Renal Failure
Leading causes are Diabetes Mellitus (50%) and Hypertension (25%).
Less common causes include, Glomerulonephritis, cytic diseases and urologic diseases
3. Test for protein in urine
Persistent proteinuria is usually the first indication of Kidney damage.
Screening for CKD involves a dip-stick evaluation of protein or evaluation for microalbuminaria
Patients with Diabetes need to have a examination for microalbuminaria if nothing is detected in routine Urinalysis
A person with persistent proteinuria (1+ or more) over a 3 month period should have further assessment of risk factors and a diagnostic work-up with blood and urine tests to evaluate for CKD
A urine test to evaluate albumin-creatinine ratio provides an accurate excretion of protein and albumin rate. A ratio greater than 300mg albumin to 1g creatinine signals CKD. It is usually tested from first voided morning specimen
Urinalysis
A urinalysis can detect presence of WBC, RBC, cast cells, protein and glucose
Ultrasound of kidneys
Usually determine the size of the kidneys
Blood examination
BUN ( blood urea nitrogen, serum creatinine and creatinine clearance levels)
Serum electrolytes
Lipid profile
Hematocrit and hemoglobin levels
Renal biopsy: for definitive diagnosis
4. Points to remember for collection of 24 hr urine specimen
Discard first urination when test is started.
Save urine for all subsequent urination for 24 hrs
Instruct patient to urinate at the end of 24 Hr and add specimen to collection
Ensure that serum creatinine is determined during 24-hr period