Question

In: Biology

Which of the following is required for efficient translation of an mRNA? Choose all that apply....

Which of the following is required for efficient translation of an mRNA? Choose all that apply.

Group of answer choices

A strong promoter

A poly A tail

A Kozak consensus sequence

A signal sequence

A 5' cap

Expert Solution

Requirement for efficient translation of an mRNA are:

A strong promoter

A 5' cap

A poly A tail

A kozak consensus sequence

Explanation- Promoter strength plays an important role in protein production. A promoter and the choice of bacterial strain will have large effects on the production of the target protein.

All eukaryotic mRNAs are modified at the 5′ end with a cap structure, which is recognized during translation initiation by the cap-binding protein eIF4E. Most eukaryotic mRNAs are also posttranscriptionally modified by the addition of a 3′ poly(A) tail.

When both 5' cap and a poly(A) tail are present on an mRNA, they function together to induce a synergistic enhancement of translation.

The Kozak consensus sequence is a nucleic acid motif that functions as the protein translation initiation site in most eukaryotic mRNA transcripts. Kozak sequence (A/GCCAUGG) enhances translation from the correct initiation codon.

Ps- An upvote would be highly appreciated

gladiator answered 2 years ago

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