Which of the following metabolic product is most likely to accumulate in a thiamin deficiency? Isocitrate...

Which of the following metabolic product is most likely to accumulate in a thiamin deficiency?

Isocitrate
Pyruvate
Succinate
Oxaloacetate
Acetyl CoA

Expert Solution

Ans.

Thiamine (vitamine B1) is one of the essential B complex vitamins that is needed in the body for the generation of energy from food.
In the efficient functioning of CNS and PNS, these vitamins play very important role.
Thiamine must be supply through the diet, as it is not produced endogenously in the human body.
Thiamine is soluble in water and liver act as it's primary storage site.
Thiamine deficiency can result in the reduced activity of thiamine dependent enzymes, which may lead to energy compromise by causing a series of metabolic events.
In thiamine deficiency, concentration of pyruvate increases because it's oxidative decarboxylation to acetyl CoA doesn't occur in deficiency of thiamine.
Then, the converion of this accumulated pyruvate into lactate occurs, which is catalyzed by lactate dehydrogenase enzyme.
This accumulation of pyruvate produces many symptoms such as, fatigue and muscle cramps.

gladiator answered 2 hours ago

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