How would a planar molecule inhibit DNA replication and an unprocessed mRNA ?

Expert Solution

Solution:

A molecule is planar when all its atom are at the same plane.

The planar molecule acts as an intercalating agent and prevents replication and transcription. It slips between layers of nucleic acid pairs and disrupts the shape of helix which affects DNA replication and mRNA transcription.

During Replication of DNA, DNA is uncoiled by helicase enzyme. This causes tension in the DNA which is relieved by topoisomerase II enzyme.

Planar molecule also causes inhibition of topoisomerase II. The role of this enzyme is to relieve the strain of DNA by cleaving the DNA chain so that both the strands can pass through each other But due to planar molecule, this tension is not resolved hence causing inhibition of DNA replication.

In mRNA transcription the double stranded DNA needs to separate so that DNA sequence can be copied. But due to inhibition of topoisomerase II the strain in DNA is not resolved which also affects mRNA transcription.

gladiator answered 2 years ago

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