1. The use of RNA primer in DNA replication increases the fidelity of DNA replication. Explain...

1. The use of RNA primer in DNA replication increases the fidelity of DNA replication. Explain this statement.

2. Some errors in DNA replication can escape repair and this is to some extent is beneficial for the evolution. Explain why?

Expert Solution

Ans 2. A human of average size has about 65 trillion cells and old cells are continuously being replaced by new cells in every minute. Each minute, about 3000 nucleotides are added in humans and in bacteria, 30,000 nucleotides are added to a new DNA chain per minute. Cellular machinary of DNA replication should work very fast in order to maintain the amazing fidelity of DNA replication. With an average of only one mistake per billion nucleotides and the correction of mistakes immediately after replication is quite amazing. Owing to replication errors and mutations results in evolution. It is ultimate source of all new genetic variation. Without this evolution cannot occur.

Ans 1. RNA primer synthsized by primases are important for begining DNA replication. It provides a free 3'-OH terminus to which nucleotides are added. DNA polymerase can't start synthesis of DNA de novo. It requires free 3'-OH on a template of DNA. DNA polymerase catalyses the formation of phopshodiester bond between primer 3' OH end and 5' -Phosphate of incoming deoxyribonucleotide. Later, primers are removed and nicks are joined by DNA ligase.

gladiator answered 1 year ago

Is RNA directly used in DNA replication? 1.RNA is not involved during the process of genome...

Is RNA directly used in DNA replication? 1.RNA is not involved during the process of genome replication 2.RNA is needed to provide the 3' -OH groups at the start of construction of new DNA 3.tRNA is matched to the codons on the genome during DNA replication 4.All of the monomers used to construct the new DNA molecule are first constructed as RNA and then a -CH3 group is added

1. What is a primer? What are they made out of during DNA replication? Why does...

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Use the six enzymes used during DNA replication to explain the process of DNA replication. Include...

Use the six enzymes used during DNA replication to explain the process of DNA replication. Include the function and purpose

9.) During the process of DNA replication, both DNA polymerase and RNA polymerase are involved in...

9.) During the process of DNA replication, both DNA polymerase and RNA polymerase are involved in eventually creating the new daughter strand of DNA. T or F 10.) Replication begins at the origin of replication or ORI and transcription begins at the first codon for methionine. T or F 11.) The process of mapping, sequencing and analysis of proteins is called genomics. T or F 12.) The heavy chain constant domains of a given immunoglobulin molecule define its class. T...

1. In what ways can a primer for DNA synthesis by a DNA polymerase be provided?...

1. In what ways can a primer for DNA synthesis by a DNA polymerase be provided? 2. In E.coli, how are the Okazaki fragments of the lagging strands joined to create a complete DNA duplex? 3. What are the three eukaryotic nuclear DNA replicases and their functions? How is DNA replication of a circular bacterial chromosome terminated?

DNA replication

For each of the following sequences, state which process, DNA replication, transcription, RNA processing, or translation,...

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Compare and contrast the accuracy of: DNA replication RNA synthesis Protein synthesis What mechanisms are used...

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Create a chart comparing and contrasting the replication strategies of DNA viruses, RNA viruses, and reverse-transcribing...

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1. What is DNA polymerase? Explain the roles of its various components in DNA replication. 2....

1. What is DNA polymerase? Explain the roles of its various components in DNA replication. 2. What is RNA polymerase? Explain its role in transcription. How is RNA polymerase similar to and different from DNA polymerase?

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