In: Nursing
Factors that determine drug transport across the blood brain barrier include all of the following except? 1. Lipid solubility 2. Charge at physiological pH 3. Renal function 4. Protein binding 5. Presence of efflux transporters
1. Lipid solubility:
The Blood-Brain Barrier does not allow the passage of lipid-soluble substances into the brain tissue. Lipophilicity lowers the amount of drug enters the brain. So the lipid solubility does not influence the drug transport across the brain.
2. Charge at Physiological PH:
The presence of positive charge of PH 7 - 8 tend to increase the Blood Brain Barrier permeability.
3. Renal Function:
The normal function of many organs influences the drug transport to the Blood-Brain Barrier. Kidney function determines the rate of blood flow to the brain.
4. Protein Binding:
Protein binding engulfs the substances and helps to pass through the cells by vesicles. The CSF proteins penetrate into the BBB.
5. Presence of efflux transporters:
Efflux transporters carry drugs out of the brain. Efflux factor (eg. P- glycoprotein) influence the passive entry of drugs into CNS.
Therefore the Factors that determine drug transport across the blood-brain barrier include all of the following except? 1. Lipid solubility