Question

Write an analysis (essay) for each of the two Questions and submit it on Canvas.           

1) This table summarizes the results from along+termrandomized clinicaltrial to  determine whether aspirin reduces the risk of heart attack. Researchers  randomly assigned a large sample of healthy male physicians (22,071) to one of  two groups. One group took a low dose of aspirin (325 mg every other day). The  other group took a placebo. Here are the final results.

Heart Attack No Heart Attack Totals Aspirin 139 10,898 11,037 Placebo 239 10,795 11,034 Totals 378 21,693 22,071

Research Question:

Does daily doses of aspirin lower the risk of a heart attack?

(Hit, some of the questions to consider

How much lower is the risk of a heart attack for those who took aspirin in the study?  

What is the relative risk of a heart attack?

  

What is the percent decrease in risk of a heart attack if someone took aspirin daily?)

Your analysis will include the following:

A Statements of the researchquestion

A description of the source of the data

A description of the variables used in the analysis

A contingency table (two-way  table)

Calculations of relevant percentages

Answer to the question based on your analysis of the data

Answer 1

1. Research Question- What is the relative risk of a heart attack?

2. Related Studies:-

https://pdfs.semanticscholar.org/7a27/a6feca6709e87a9163867101d5d7ad684619.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979389/

3. , the appropriate dose of aspirin to prevent myocardial infarction (MI) and stroke is uncertain. In the US, the doses most frequently recommended are 80, 160, or 325 mg per day. Because aspirin can cause major bleeding, the appropriate dose is the lowest dose that is effective in preventing both MI and stroke because these two diseases frequently co-exist

• There is general agreement that the appropriate dose to prevent myocardial infarction and stroke is 325 mg/day or less. The most frequently recommended doses are 81 mg, 160 mg, or 325 mg/day.

? In randomized clinical trials, doses of less than 160 mg/day were ineffective in the primary prevention of stroke or myocardial infarction.

? In randomized clinical trials, the risk of major bleeding was the same for those taking 81 or 160 mg/day, 1 to 2 cases per 1000 years of treatment.

? These studies indicate that the most appropriate dose of aspirin to prevent myocardial infarction and stroke is 160 mg/day.

4. Contingency Table

	Heart Attack	No Heart Attack	Totals
Aspirin	139	10,898	11,037
Placebo	239	10,795	11,034
Totals	378	21,693	22,071

5. Calculation of Percentages

(a)

(b) RELATIVE RISK

So Relative Risk =(139/11037) / (239/11034)

=0.01259/0.02166 =0.5812